Premium
Frontispiece: A Novel Cathode Material for Cathodic Dehalogenation of 1,1‐Dibromo Cyclopropane Derivatives
Author(s) -
Gütz Christoph,
Selt Maximilian,
Bänziger Markus,
Bucher Christoph,
Römelt Christina,
Hecken Nadine,
Gallou Fabrice,
Galvão Tomás R.,
Waldvogel Siegfried R.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201584061
Subject(s) - halogenation , cyclopropane , cathode , electrochemistry , electrolysis , yield (engineering) , cathodic protection , metal , chemistry , materials science , combinatorial chemistry , inorganic chemistry , organic chemistry , metallurgy , electrode , ring (chemistry) , electrolyte
Pharmaceutical Electrochemistry . The electrochemical dehalogenation represents a powerful and sustainable tool for the synthesis of pharmaceutically relevant cyclopropane building blocks in excellent yield. The key to the conversion is the leaded bronze cathode instead of traditional lead. This novel cathode material is less prone to corrosion and provides highly pure product. Thereby, contamination by heavy metal traces is tremendously reduced. Furthermore, by slightly switching the electrolysis conditions, selective mono‐ or twofold dehalogenation is achieved. For more details, see the Communication by S. R. Waldvogel and co‐workers on page 13878 ff.