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Frontispiece: Combining Crystallography and Hydrogen–Deuterium Exchange to Study Galectin–Ligand Complexes
Author(s) -
Ruiz Federico M.,
Gilles Ulrich,
Lindner Ingo,
André Sabine,
Romero Antonio,
Reusch Dietmar,
Gabius HansJoachim
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201583962
Subject(s) - hydrogen–deuterium exchange , galectin 3 , galectin , lectin , chemistry , ligand (biochemistry) , adhesion , hydrogen , biochemistry , nanotechnology , computational biology , materials science , biology , receptor , organic chemistry , immunology
Proteins . Their ability to translate sugar‐encoded information into bioeffects attracts attention to the structural analysis of lectins. A key question concerns the identification of the contact site for ligands. Teamed up with crystallographical data, the reliability and sensitivity of hydrogen–deuterium exchange are documented for an adhesion/growth‐regulatory lectin tested as model. For more details see the Full Paper on page 13558 ff. by S. André, A. Romero, D. Reusch and co‐workers.