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Inside Back Cover: Tetraphenylethene Derivatives with Different Numbers of Positively Charged Side Arms have Different Multimeric G‐Quadruplex Recognition Specificity (Chem. Eur. J. 38/2015)
Author(s) -
Zhang Qi,
Liu YanChen,
Kong DeMing,
Guo DongSheng
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201583803
Subject(s) - g quadruplex , chemistry , dna , side chain , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , polymer
G‐quadruplex (G4) is a noncanonical secondary DNA structure formed by G‐rich sequences that are widespread in biologically important regions of the human genome. In their Full Paper on page 13253 ff. , D.‐M. Kong, D.‐S. Guo, and co‐workers describe the synthesis of two TPE derivatives and the investigation into their potential use as multimeric G4 bioprobes. It was determined from this study that the difference in the number of positively charged side arms confers the two derivatives with different multimeric G4 recognition specificity.