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Inside Cover: Cu‐Catalyzed Cyanation of Arylboronic Acids with Acetonitrile: A Dual Role of TEMPO (Chem. Eur. J. 38/2015)
Author(s) -
Zhu Yamin,
Li Linyi,
Shen Zengming
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201583802
Subject(s) - acetonitrile , catalysis , cyanation , hourglass , reagent , chemistry , dual role , solvent , copper , medicinal chemistry , photochemistry , polymer chemistry , combinatorial chemistry , organic chemistry , physics , astronomy
The hourglass represents the catalytic system. The upper half of the hourglass is filled with acetonitrile solvent, copper catalyst, Si reagent, and TEMPO (2,2,6,6‐tetramethylpiperidine N ‐oxide). The CN − ion generated from acetonitrile is dropping down, like grains of sand, to the bottom of the hourglass. In the system, it is noted that acetonitrile is an effective cyano source. The copper catalyst and the TEMPO occupy the most important positions in the hourglass, showing that they are the critical reagents in accelerating the CCN bond cleavage and promoting the reaction smoothly. The background is a book that reveals the specific reaction and the possible mechanism. More details about this catalytic system can be found in the Full Paper by Z. Shen and co‐workers on page 13246 ff.