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Frontispiece: Divergent Synthesis of Aeruginosins Based on a C(sp 3 )H Activation Strategy
Author(s) -
Dailler David,
Danoun Grégory,
Ourri Benjamin,
Baudoin Olivier
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201582662
Subject(s) - proteases , trypsin , chemistry , serine , thrombin , stereochemistry , serine protease , in vitro , enzyme , biochemistry , biology , protease , platelet , immunology
Marine Natural Products Aeruginosins are marine natural products that have been isolated from sponges and cyanobacterial water blooms. Among these, aeruginosin 298A, 98A–C, and 101 have shown potent in vitro inhibition of various serine proteases, including thrombin and trypsin. In their Full Paper on page 9370 ff. , O. Baudoin et al. describe the total synthesis of aeruginosins 98A–C and 298A by the use of two different Pd‐catalyzed C(sp 3 )H activation reactions, with aeruginosin 298A synthesized on an unprecedentedly large scale.