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Frontispiece: Biomolecular Assemblies Combining Two Orthogonal Copper‐Mediated Ligations in a One‐Pot Reaction
Author(s) -
Grassin Adrien,
Claron Michaël,
Boturyn Didier
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201581661
Subject(s) - alkyne , ligation , amine gas treating , azide , copper , combinatorial chemistry , click chemistry , chemistry , organic chemistry , biology , catalysis , microbiology and biotechnology
Click Chemistry Biomolecular assemblies are essential to construct macromolecules encompassing several biorelevant functions. A new method that involves two orthogonal copper‐mediated ligations of azide with alkyne, and amine with thioacid, was developed for the ligation of three different chemical components. Interestingly, it was observed that the ligation of azide with alkyne was found to be faster than the ligation of amine with thioacid. For more details, see the Communication by D. Boturyn et al. on page 6022 ff.