Premium
Frontispiece: A Simple Iridicycle Catalyst for Efficient Transfer Hydrogenation of N‐Heterocycles in Water
Author(s) -
Talwar Dinesh,
Li Ho Yin,
Durham Emma,
Xiao Jianliang
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201581462
Subject(s) - transfer hydrogenation , catalysis , hydride , chemistry , quinoline , aqueous solution , formate , iridium , solvent , combinatorial chemistry , organic chemistry , ruthenium , hydrogen
Transfer hydrogenation Transfer hydrogenation is a simple safe way for reduction reactions and using water as a solvent has the additional benefit of being “green”. In their Full paper on page 5370 ff., J. Xiao et al. report that a cyclometalated iridium complex catalyzes the transfer hydrogenation of various nitrogen heterocycles in an aqueous solution of formate under mild conditions. The catalyst shows excellent functional‐group compatibility and high turnover number, with loadings as low as 0.01 mol % being feasible. A mechanistic study of quinoline reduction suggests that the reaction proceeds via both 1,2‐ and 1,4‐addition pathways, with the catalytic turnover limited by hydride transfer.