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Frontispiece: Tetraloop‐like Geometries Could Form the Basis of the Catalytic Activity of the Most Ancient Ribooligonucleotides
Author(s) -
Stadlbauer Petr,
Šponer Jiří,
Costanzo Giovanna,
Di Mauro Ernesto,
Pino Samanta,
Šponer Judit E.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201580962
Subject(s) - ribozyme , hairpin ribozyme , oligonucleotide , crystallography , chemistry , stereochemistry , rna , dna , biochemistry , gene
Oligonucleotides In their Full Paper on page 3596 ff., J. E. Šponer et al. report on the results of molecular dynamics (MD) simulations used to investigate whether tetraloop‐like overhang geometries might give rise to ribozyme‐like activity in short Watson–Crick complementary oligoG/oligoC sequences. Their results demonstrate that the studied tetraloop‐like overhang geometries are able to stabilize the 2′‐ and 3′‐OH groups of the acceptor ribose in the vicinity of the phosphate of the donor strand for several tens to hundreds of nanoseconds, which is entirely sufficient for the required transphosphorylation reactions to proceed.