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Frontispiece: Cell Penetrating Synthetic Antimicrobial Peptides (SAMPs) Exhibiting Potent and Selective Killing of Mycobacterium by Targeting Its DNA
Author(s) -
Sharma Aashish,
Pohane Amol Arunrao,
Bansal Sandhya,
Bajaj Avinash,
Jain Vikas,
Srivastava Aasheesh
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201580961
Subject(s) - mycobacterium smegmatis , antimicrobial , lytic cycle , antimicrobial peptides , escherichia coli , internalization , bacteria , microbiology and biotechnology , dna , lipopolysaccharide , mycobacterium , biology , chemistry , cell , biochemistry , virology , gene , mycobacterium tuberculosis , medicine , immunology , genetics , virus , tuberculosis , pathology
Synthetic Antimicrobial Peptides Natural antimicrobial peptides are an integral part of the defense mechanism of many organisms. In their Communication on page 3540 ff. , A. Bajaj, V. Jain, A. Srivastava et al. report on polyaspartamides that act as non‐membrane‐lytic synthetic antimicrobial peptides (SAMPs), selectively killing Mycobacterium smegmatis over Escherichia coli or mammalian cells. The antibacterial action is linked to cellular uptake of these SAMPs, which is inhibited in E. coli by the lipopolysaccharide (LPS) layer. Upon internalization, the SAMPs interact with the exposed genomic DNA of bacteria, killing the bacteria as a consequence.