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Iron‐Catalyzed Allylic Amination Directly from Allylic Alcohols
Author(s) -
Emayavaramban Balakumar,
Roy Moumita,
Sundararaju Basker
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201505214
Subject(s) - allylic rearrangement , amination , chemistry , catalysis , reductive amination , organic chemistry , redox , allylic alcohol , lewis acids and bases , cinnamyl alcohol , combinatorial chemistry , selectivity
Allylic amination, directly from alcohols, has been demonstrated without any Lewis acid activators using an efficient and regiospecific molecular iron catalyst. Various amines and alcohols were employed and the reaction proceeded through the oxidation/reduction (redox) pathway. A direct one‐step synthesis of common drugs, such as cinnarizine and nafetifine, was exhibited from cinnamyl alcohol that produced water as side product.