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Cytotoxicity of Postmodified Zeolitic Imidazolate Framework‐90 (ZIF‐90) Nanocrystals: Correlation between Functionality and Toxicity
Author(s) -
Yen ChiaI,
Liu SzuMam,
Lo WeiShang,
Wu JheWei,
Liu YiHsin,
Chein RongJie,
Yang Renqiang,
Wu Kevin C.W.,
Hwu Jih Ru,
Ma Nianhan,
Shieh FaKuen
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201505005
Subject(s) - cytotoxicity , zeolitic imidazolate framework , chemistry , imidazolate , aldehyde , combinatorial chemistry , toxicity , nanocrystal , in vitro , biochemistry , organic chemistry , nanotechnology , metal organic framework , materials science , catalysis , adsorption
Using a simple method, the aldehyde groups of zeolitic imidazolate framework‐90 (ZIF‐90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated‐ZIF‐90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half‐maximal effective (EC 50 ) concentration of aminated‐ZIF‐90 has a higher cytotoxicity of about 30 μg mL −1 .