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Lipid Nanotube Tailored Fabrication of Uniquely Shaped Polydopamine Nanofibers as Photothermal Converters
Author(s) -
Ding Wuxiao,
Chechetka Svetlana A.,
Masuda Mitsutoshi,
Shimizu Toshimi,
Aoyagi Masaru,
Minamikawa Hiroyuki,
Miyako Eijiro
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504958
Subject(s) - nanofiber , materials science , photothermal therapy , template , photothermal effect , nanotechnology , fabrication , absorbance , chemistry , chromatography , medicine , alternative medicine , pathology
Helically coiled and linear polydopamine (PDA) nanofibers were selectively fabricated with two different types of lipid nanotubes (LNTs) that acted as templates. The obtained coiled PDA‐LNT hybrid showed morphological advantages such as higher light absorbance and photothermal conversion effect compared to a linear counterpart. Laser irradiation of the coiled PDA‐LNT hybrid induced a morphological change and subsequent release of the encapsulated guest molecule. In cellular experiments, the coiled PDA‐LNT efficiently eliminated HeLa cells because of its strong affinity with the tumor cells. This work illustrates the first approach to construct characteristic morphologies of PDA nanofibers using LNTs as simple templates, and the coiled PDA‐LNT hybrid exhibits attractive photothermal features derived from its unique coiled shape.