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Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors
Author(s) -
Byrd Katherine M.,
Subramanian Chitra,
Sanchez Jacqueline,
Motiwala Hashim F.,
Liu Weiya,
Cohen Mark S.,
Holzbeierlein Jeffrey,
Blagg Brian S. J.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504955
Subject(s) - novobiocin , amide , coumarin , chemistry , sugar , hsp90 , core (optical fiber) , biochemistry , combinatorial chemistry , heat shock protein , stereochemistry , organic chemistry , materials science , gene , composite material , antibiotics
Development of heat shock protein 90 (Hsp90) C‐terminal inhibitors has emerged as an exciting strategy for the treatment of cancer. Previous efforts have focused on modifications to the natural products novobiocin and coumermycin. Moreover, variations in both the sugar and amide moieties have been extensively studied, whereas replacements for the coumarin core have received less attention. Herein, 24 cores were synthesized with varying distances and angles between the sugar and amide moieties. Compounds that exhibited good anti‐proliferative activity against multiple cancer cell lines and Hsp90 inhibitory activity, were those that placed the sugar and amide moieties between 7.7 and 12.1 Å apart along with angles of 180°.