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Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin
Author(s) -
Schmidt Andrea,
Molano Viviana,
Hollering Manuela,
Pöthig Alexander,
Casini Angela,
Kühn Fritz E.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504930
Subject(s) - cisplatin , in vivo , pharmacology , chemistry , ex vivo , drug delivery , drug , toxicity , in vitro , ovarian cancer , supramolecular chemistry , cancer research , cancer , biochemistry , medicine , biology , chemotherapy , crystal structure , microbiology and biotechnology , organic chemistry , crystallography
Self‐assembled metallocages are very promising drug‐delivery systems among supramolecular complexes. Thus, exo ‐functionalized Pd 2 L 4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative effects of the metallocages and their combination with cisplatin were examined in vitro in cancer cell lines, while fluorescence microscopy was used to monitor their uptake. Notably, the hydroxymethyl‐functionalized Pd II cage encapsulating cisplatin showed improved cytotoxic effect against human ovarian cancer cells compared to free cisplatin. The toxicity of Pd 2 L 4 cages was evaluated for the first time ex vivo in healthy rat‐liver tissues using the precision cut‐tissue slices technology, demonstrating in some cases scarce effects on liver viability. These results further highlight the potential of self‐assembled Pd 2 L 4 cages for biological applications.