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Inside Back Cover: Total Synthesis and Biological Assessment of Mandelalide A (Chem. Eur. J. 4/2016)
Author(s) -
Brütsch Tobias Michael,
Bucher Pascal,
Altmann KarlHeinz
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504918
Subject(s) - polyketide , natural product , total synthesis , stereochemistry , cover (algebra) , cancer cell lines , potency , chemistry , cell culture , computational biology , biology , combinatorial chemistry , cancer , biochemistry , cancer cell , biosynthesis , gene , in vitro , genetics , engineering , mechanical engineering
The picture shows the marine macrolide mandelalide A together with the starting materials and advanced intermediates that have enabled a highly convergent total synthesis of the macrolactone core of this complex natural product. Like other bioactive macrocycles, mandelalide A is of polyketide origin and it has been described to exhibit antiproliferative activity against some human cancer cell lines, but not others. Here, mandelalide A was found to reduce the proliferation of two lung cancer cell lines with n M potency, but it did not kill all cells even at much higher concentrations. More information can be found in the Full Paper by K.‐H. Altmann et al. on page 1292 ff.