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Microwave‐Assisted Copper‐Catalyzed Oxidative Cyclization of Acrylamides with Non‐Activated Ketones
Author(s) -
Zhao Yaping,
Sharma Nandini,
Sharma Upendra K.,
Li Zhenghua,
Song Gonghua,
Van der Eycken Erik V.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504776
Subject(s) - catalysis , oxidative phosphorylation , chemistry , tandem , combinatorial chemistry , acrylamide , copper , organic chemistry , materials science , biochemistry , copolymer , composite material , polymer
An operationally simple and efficient microwave‐assisted protocol for the oxidative cyclization of acrylamide derivatives with non‐activated ketones to generate 3,3‐disubstituted oxindoles is described. The reaction proceeds by a copper‐catalyzed tandem radical addition/cyclization strategy and tolerates a series of functional groups with moderate to excellent yields.