Premium
Ultrasmall Superparamagnetic Iron Oxide Nanoparticles with Europium(III) DO3A as a Bimodal Imaging Probe
Author(s) -
Carron Sophie,
Bloemen Maarten,
Vander Elst Luce,
Laurent Sophie,
Verbiest Thierry,
ParacVogt Tatja.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504731
Subject(s) - europium , nanoparticle , superparamagnetism , materials science , lanthanide , mri contrast agent , luminescence , luminophore , iron oxide , analytical chemistry (journal) , ion , chemistry , nanotechnology , optoelectronics , chromatography , organic chemistry , magnetization , metallurgy , physics , quantum mechanics , magnetic field
A new prototype consisting of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles decorated with europium(III) ions encapsulated in a DO3A organic scaffold was designed as a platform for further development of bimodal contrast agents for MRI and optical imaging. The USPIO nanoparticles act as negative MRI contrast agents, whereas the europium(III) ion is a luminophore that is suitable for use in optical imaging detection. The functionalized USPIO nanoparticles were characterized by TEM, DLS, XRD, FTIR, and TXRF analysis, and a full investigation of the relaxometric and optical properties was conducted. The typical luminescence emission of europium(III) was observed and the main red emission wavelength was found at 614 nm. The relaxometric study of these ultrasmall nanoparticles showed r 2 values of 114.8 m m −1 Fe s −1 at 60 MHz, which is nearly double the r 2 relaxivity of Sinerem ® .