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Biodegradable Peptide–Silica Nanodonuts
Author(s) -
Maggini Laura,
Travaglini Leana,
Cabrera Ingrid,
CastroHartmann Pablo,
De Cola Luisa
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504605
Subject(s) - nanocarriers , hela , peptide , doxorubicin , drug delivery , exocytosis , chemistry , nanotechnology , materials science , biophysics , biochemistry , membrane , biology , cell , genetics , chemotherapy
We report hybrid organosilica toroidal particles containing a short peptide sequence as the organic component of the hybrid systems. Once internalised in cancer cells, the presence of the peptide allows for interaction with peptidase enzymes, which attack the nanocarrier effectively triggering its structural breakdown. Moreover, these biodegradable nanovectors are characterised by high cellular uptake and exocytosis, showing great potential as biodegradable drug carriers. To demonstrate this feature, doxorubicin was employed and its delivery in HeLa cells investigated.