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Prefolded Synthetic G‐Quartets Display Enhanced Bioinspired Properties
Author(s) -
Flack Theodore,
Constantin Thibaut,
Penasse Sylvain,
Dejeu Jérôme,
Gennaro Béatrice,
Jourdan Muriel,
Laguerre Aurélien,
Pirrotta Marc,
Monchaud David,
Spinelli Nicolas,
Defrancq Eric
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504572
Subject(s) - deoxyribozyme , boosting (machine learning) , intramolecular force , g quadruplex , nanotechnology , chemistry , combinatorial chemistry , guanine , materials science , stereochemistry , computer science , biochemistry , dna , artificial intelligence , nucleotide , gene
A water‐soluble template‐assembled synthetic G‐quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties. Comparison of its DNAzyme‐boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme‐boosting agent.