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Inside Cover: Collective Synthesis and Biological Evaluation of Tryptophan‐Based Dimeric Diketopiperazine Alkaloids (Chem. Eur. J. 4/2016)
Author(s) -
Tadano Shinji,
Sugimachi Yukihiro,
Sumimoto Michinori,
Tsukamoto Sachiko,
Ishikawa Hayato
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504560
Subject(s) - tryptophan , chemistry , combinatorial chemistry , cover (algebra) , amino acid , stereochemistry , computational biology , biochemistry , biology , mechanical engineering , engineering
Concise two one‐pot syntheses of tryptophan‐based dimeric diketopiperazine alkaloids have been accomplished by using the bio‐inspired dimerization reaction of tryptophan derivatives in water as the key step. Eleven natural products are obtained by using the developed simple protocols with different amino acids. In addition, some of these synthetic alkaloids are discovered as new drug candidates for cancer therapy or atherosclerosis therapy. More information can be found in the Full Paper by H. Ishikawa et al. on page 1277 ff.