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Inside Cover: Stereoselective Synthesis of 1,3‐Diaminotruxillic Acid Derivatives: An Advantageous Combination of CH‐ ortho ‐Palladation and On‐Flow [2+2]‐Photocycloaddition in Microreactors (Chem. Eur. J. 1/2016)
Author(s) -
Serrano Elena,
Juan Alberto,
GarcíaMontero Angel,
Soler Tatiana,
JiménezMárquez Francisco,
Cativiela Carlos,
Gomez M. Victoria,
Urriolabeitia Esteban P.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504558
Subject(s) - microreactor , stereoselectivity , chemistry , cover (algebra) , flow chemistry , stereochemistry , catalysis , organic chemistry , mechanical engineering , engineering
The stereoselective synthesis of 1,3‐diaminotruxillic acid derivatives has been achieved in high yields and short reaction times. The procedure starts from simple 5(4 H )‐ oxazolones and is based on an efficient combination of CH orthopalladation, [2+2]‐photocycloaddition on continuous flow microreactors using visible light from LED sources, and hydrogenation to selectively afford the epsilon isomer. More information can be found in the Full Paper by E. P. Urriolabeitia, M. V. Gómez, C. Cativiela et al. on page 144 ff.