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AIE Luminogen‐Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging
Author(s) -
Fan Zhiying,
Li Dongdong,
Yu Xue,
Zhang Yuping,
Cai Yong,
Jin Jingji,
Yu Jihong
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504377
Subject(s) - mesoporous silica , biocompatibility , doxorubicin hydrochloride , drug delivery , mesoporous material , materials science , nanotechnology , aggregation induced emission , luminescence , chemical engineering , doxorubicin , chemistry , fluorescence , organic chemistry , optoelectronics , medicine , physics , surgery , engineering , chemotherapy , quantum mechanics , metallurgy , catalysis
Hollow mesoporous silica nanospheres functionalized with aggregation‐induced emission (AIE) luminogen tetraphenylethene were prepared by postgrafting method. The as‐prepared inorganic–organic hybrid nanospheres show bright blue emission and good biocompatibility as shown by MTT assays. The large cavities of the materials enable high loading of the anticancer drug doxorubicin hydrochloride (DOX), and the mesoporous silica shells allow pH‐dependent drug release. The materials can be effectively taken up by cells and function as luminescent bioprobes, demonstrating their potential application in imaging‐guided therapy.