Autoxidation/Aldol Tandem Reaction of 2‐Oxindoles with Ketones: A Green Approach for the Synthesis of 3‐Hydroxy‐2‐Oxindoles | Zendy

Zhang QingBao | Zendy; Jia WenLiang | Zendy; Ban YongLiang | Zendy; Zheng Yong | Zendy; Liu Qiang | Zendy; Wu LiZhu | Zendy

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Autoxidation/Aldol Tandem Reaction of 2‐Oxindoles with Ketones: A Green Approach for the Synthesis of 3‐Hydroxy‐2‐Oxindoles

Author(s) -

Zhang QingBao,

Jia WenLiang,

Ban YongLiang,

Zheng Yong,

Liu Qiang,

Wu LiZhu

Publication year - 2016

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201504282

Subject(s) - autoxidation , chemistry , tandem , aldol reaction , alkyl , organic chemistry , reaction conditions , cascade reaction , combinatorial chemistry , catalysis , materials science , composite material

In the presence of tetrabutylammonium fluoride and molecular sieves (MS) 4 Å in DMF, an efficient autoxidation reaction of 2‐oxindoles with ketones under air at room temperature has been developed. This approach may provide a green, practical, and metal‐free protocol for a wide range of biologically important 3‐hydroxy‐3‐(2‐oxo‐alkyl)‐2‐oxindoles.

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