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Cerasomes: Soft Interface for Redox Enzyme Electrochemical Signal Transmission
Author(s) -
Qiao Yun,
Tahara Keishiro,
Zhang Qian,
Song XiMing,
Kikuchi Junichi
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201504042
Subject(s) - liposome , materials science , bilayer , nanoparticle , horseradish peroxidase , biocompatibility , nanotechnology , electrode , biosensor , electrochemistry , chemical engineering , lipid bilayer , bioelectronics , membrane , chemistry , organic chemistry , biochemistry , enzyme , engineering , metallurgy
Anionic cerasomes, which consist of a liposomal lipid bilayer and a ceramic surface, were used as a soft interface for the construction of an integrated modified electrode to achieve the transmission of chemical information from a redox enzyme through electrical signals. The morphological properties of the cerasomes were systematically compared with those of two structural analogues, namely, liposomes and silica nanoparticles. The results indicated that the cerasomes combined the advantages of liposomes and silica nanoparticles. The lipid bilayer gave excellent biocompatibility, as in the case of liposomes, and high structural stability, similar to that of silica nanoparticles, was derived from the silicate framework on the cerasome surface. The performance at the electrochemical interface created by means of a combination of cerasomes and horseradish peroxidase on a glassy carbon electrode was much better than those achieved with liposomes or silica nanoparticles instead of cerasomes. The potential use of cerasomes in the construction of supramolecular devices for mediator‐free biosensing was evaluated.