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Acetaldehyde: A Small Organic Molecule with Big Impact on Organocatalytic Reactions
Author(s) -
Kim Sun Min,
Kim Young Sug,
Kim Dong Wan,
Rios Ramon,
Yang Jung Woon
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503960
Subject(s) - synthon , enantioselective synthesis , organocatalysis , acetaldehyde , heteroatom , chemistry , organic chemistry , organic synthesis , carbon fibers , catalysis , combinatorial chemistry , ring (chemistry) , materials science , composite number , ethanol , composite material
Stereocontrolled formation of carbon−carbon and carbon−heteroatom bonds through asymmetric organocatalysis is a formidable challenge for modern synthetic chemistry. Among the most significant contributions to this field are the transformations involving the use of acetaldehyde or α‐heteroatom‐substituted acetaldehydes for constructing valuable synthons (e.g., amino acid derivatives and hydroxycarbonyl). In this Minireview, versatile (enantioselective) organocatalytic transformations are discussed.