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Structure of Amido Pyridinium Betaines: Persistent Intermolecular C−H⋅⋅⋅N Hydrogen Bonding in Solution
Author(s) -
Thatcher Robert J.,
Johnson David G.,
Slattery John M.,
Douthwaite Richard E.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503884
Subject(s) - hydrogen bond , chemistry , intermolecular force , molecule , low barrier hydrogen bond , chemical bond , hydrogen , crystallography , computational chemistry , organic chemistry
A hydrogen bond of the type C−H⋅⋅⋅X (X=O or N) is known to influence the structure and function of chemical and biological systems in solution. C−H⋅⋅⋅O hydrogen bonding in solution has been extensively studied, both experimentally and computationally, whereas the equivalent thermodynamic parameters have not been enumerated experimentally for C−H⋅⋅⋅N hydrogen bonds. This is, in part, due to the lack of systems that exhibit persistent C−H⋅⋅⋅N hydrogen bonds in solution. Herein, a class of molecule based on a biologically active norharman motif that exhibits unsupported intermolecular C−H⋅⋅⋅N hydrogen bonds in solution has been described. A pairwise interaction leads to dimerisation to give bond strengths of about 7 kJ mol −1 per hydrogen bond, which is similar to chemically and biologically relevant C−H⋅⋅⋅O hydrogen bonding. The experimental data is supported by computational work, which provides additional insight into the hydrogen bonding by consideration of electrostatic and orbital interactions and allowed a comparison between calculated and extrapolated NMR chemical shifts.