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Probing the Limits of Selectivity in a Recognition‐Mediated Reaction Network Embedded within a Dynamic Covalent Library
Author(s) -
Kosikova Tamara,
Mackenzie Harry,
Philp Douglas
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503740
Subject(s) - covalent bond , nucleophile , binary number , selectivity , computer science , resolution (logic) , chemistry , combinatorial chemistry , pattern recognition (psychology) , artificial intelligence , biological system , organic chemistry , biology , mathematics , catalysis , arithmetic
Two recognition‐mediated reaction processes operating through reactive binary complexes drive resolution of a 24‐component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition‐enabled species over another is limited by the difference in the rates of the recognition‐mediated reactive processes and the strength of the recognition processes employed in the dynamic system.