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Copper‐Catalyzed Aerobic Decarboxylation/Ketooxygenation of Electron‐Deficient Alkenes
Author(s) -
Lu Qingquan,
Peng Pan,
Luo Yi,
Zhao Ying,
Zhou Minxian,
Lei Aiwen
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503716
Subject(s) - decarboxylation , chemistry , catalysis , copper , oxidative decarboxylation , salt (chemistry) , photochemistry , medicinal chemistry , inorganic chemistry , organic chemistry
Abstract A copper‐catalyzed ketooxygenation of electron‐deficient alkenes was developed. This approach combines OH alkylation, aerobic decarboxylation, and oxygenation in one transformation. Mechanistic investigation of this reaction showed that the copper salt is responsible for both generating the amidoxyl radical and promoting aerobic decarboxylation.