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Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal–Organic Framework
Author(s) -
Sun Raymond WaiYin,
Zhang Ming,
Li Dan,
Zhang ZhiFeng,
Cai Hong,
Li Mian,
Xian YueJiao,
Ng Seik Weng,
Wong Alice SzeTsai
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503656
Subject(s) - cytotoxic t cell , metal , nanotechnology , chemistry , materials science , organic chemistry , in vitro , biochemistry
A dinuclear gold(I) pyrrolidinedithiocarbamato complex ( 1 ) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin‐resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)‐based metal–organic framework (Zn‐MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug‐release testing, in this study, a set of transwell assay‐based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1 @Zn‐MOF towards A2780cis.