Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal–Organic Framework | Zendy

Sun Raymond WaiYin | Zendy; Zhang Ming | Zendy; Li Dan | Zendy; Zhang ZhiFeng | Zendy; Cai Hong | Zendy; Li Mian | Zendy; Xian YueJiao | Zendy; Ng Seik Weng | Zendy; Wong Alice SzeTsai | Zendy

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Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal–Organic Framework

Author(s) -

Sun Raymond WaiYin,

Zhang Ming,

Li Dan,

Zhang ZhiFeng,

Cai Hong,

Li Mian,

Xian YueJiao,

Ng Seik Weng,

Wong Alice SzeTsai

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201503656

Subject(s) - cytotoxic t cell , metal , nanotechnology , chemistry , materials science , organic chemistry , in vitro , biochemistry

A dinuclear gold(I) pyrrolidinedithiocarbamato complex ( 1 ) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin‐resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)‐based metal–organic framework (Zn‐MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug‐release testing, in this study, a set of transwell assay‐based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1 @Zn‐MOF towards A2780cis.

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