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Cobalt(III)‐Catalyzed Dehydrative [4+2] Annulation of Oxime with Alkyne by CH and NOH Activation
Author(s) -
Sen Malay,
Kalsi Deepti,
Sundararaju Basker
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503643
Subject(s) - annulation , alkyne , oxime , cobalt , catalysis , chemistry , medicinal chemistry , organic chemistry
Efficient, scalable cobalt‐catalyzed redox‐neutral [4+2] annulation of readily available oximes and alkyne is reported. The developed synthetic methodology is widely applicable and tolerates various functional groups including heterocycles. A stable Cp*Co III neutral complex is employed as the catalyst for this redox‐neutral [4+2] annulation reaction, which progresses smoothly by way of a reversible cyclometallation without any external oxidizing agent, and produces only water as the side product.