Cationic Cobalt(III)‐Catalyzed Aryl and Alkenyl CH Amidation: A Mild Protocol for the Modification of Purine Derivatives | Zendy

Liang Yujie | Zendy; Liang YuFeng | Zendy; Tang Conghui | Zendy; Yuan Yizhi | Zendy; Jiao Ning | Zendy

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Cationic Cobalt(III)‐Catalyzed Aryl and Alkenyl CH Amidation: A Mild Protocol for the Modification of Purine Derivatives

Author(s) -

Liang Yujie,

Liang YuFeng,

Tang Conghui,

Yuan Yizhi,

Jiao Ning

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201503533

Subject(s) - cationic polymerization , chemistry , catalysis , cobalt , reagent , combinatorial chemistry , antimycobacterial , aryl , substrate (aquarium) , purine , surface modification , medicinal chemistry , organic chemistry , enzyme , alkyl , mycobacterium tuberculosis , medicine , tuberculosis , oceanography , pathology , geology

A cationic cobalt(III)‐catalyzed direct CH amidation of unactivated (hetero)arenes and alkenes by using 1,4,2‐dioxazol‐5‐ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant‐free conditions with a broad substrate scope. Moreover, 6‐arylpurine compounds, which often exhibit high potency in antimycobacterial, cytostatic, and anti‐HCV activities, can be smoothly amidated, thus offering a mild protocol for their late stage functionalization.

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