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Palladium(II)‐Catalyzed Acetoxime Directed ortho ‐Arylation of Aromatic Alcohols
Author(s) -
Guo Kun,
Chen Xiaolan,
Zhang Jingyu,
Zhao Yingsheng
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503284
Subject(s) - palladium , chemistry , hydroxylamine , catalysis , yield (engineering) , ligand (biochemistry) , organic chemistry , combinatorial chemistry , materials science , biochemistry , receptor , metallurgy
Biaryls, which contained a benzyloxy motif, were directly constructed through a ligand‐promoted Pd II ‐catalyzed ortho ‐arylation of masked aromatic alcohols. A variety of acetoxime ethers could be coupled with a diverse range of arylboronic acid pinocol esters, giving direct access to bioactive biaryls in modest to good yield. Not only could acetoxime be subsequently removed without a separation, functionalized hydroxylamine derivatives could also be obtained.