Palladium(II)‐Catalyzed Acetoxime Directed  ortho ‐Arylation of Aromatic Alcohols | Zendy

Guo Kun | Zendy; Chen Xiaolan | Zendy; Zhang Jingyu | Zendy; Zhao Yingsheng | Zendy

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Palladium(II)‐Catalyzed Acetoxime Directed ortho ‐Arylation of Aromatic Alcohols

Author(s) -

Guo Kun,

Chen Xiaolan,

Zhang Jingyu,

Zhao Yingsheng

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201503284

Subject(s) - palladium , chemistry , hydroxylamine , catalysis , yield (engineering) , ligand (biochemistry) , organic chemistry , combinatorial chemistry , materials science , biochemistry , receptor , metallurgy

Biaryls, which contained a benzyloxy motif, were directly constructed through a ligand‐promoted Pd II ‐catalyzed ortho ‐arylation of masked aromatic alcohols. A variety of acetoxime ethers could be coupled with a diverse range of arylboronic acid pinocol esters, giving direct access to bioactive biaryls in modest to good yield. Not only could acetoxime be subsequently removed without a separation, functionalized hydroxylamine derivatives could also be obtained.

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