Premium
To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe III –Porphyrin Center
Author(s) -
Tseng YuTing,
Chen ChienHong,
Lin JingYu,
Li BingHan,
Lu YuHuan,
Lin ChiaHer,
Chen HsinTsung,
Weng TsuChien,
Sokaras Dimosthenes,
Chen HuangYeh,
Soo YunLiang,
Lu TsaiTe
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503176
Subject(s) - porphyrin , nitroxyl , center (category theory) , chemistry , photochemistry , crystallography
A positive myocardial inotropic effect achieved using HNO/NO − , compared with NO⋅, triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M‐NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl‐transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a Fe III ‐porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO) 2 } 9 DNIC [Fe(μ‐ Me Pyr)(NO) 2 ] 2 was discovered as a potent nitroxyl donor for nitroxylation of Fe III ‐heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies.