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Short Convergent Synthesis of the Mycolactone Core Through Lithiation–Borylation Homologations
Author(s) -
Brown Christopher A.,
Aggarwal Varinder K.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503122
Subject(s) - borylation , convergence (economics) , core (optical fiber) , convergent synthesis , yield (engineering) , computer science , chemistry , combinatorial chemistry , materials science , organic chemistry , telecommunications , alkyl , aryl , economics , metallurgy , economic growth
Using iterative lithiation–borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17 % overall yield. The rapid build‐up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis.