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One‐Pot Synthesis of Hydrophobically Modified Iminosugar C ‐Alkynylglycosides: Facile Synthesis of Polyhydroxy Tetrahydroindolizines
Author(s) -
Senthilkumar Soundararasu,
Prasad Sure Siva,
Das Amrita,
Baskaran Sundarababu
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201503047
Subject(s) - iminosugar , chemistry , materials science , polymer science , combinatorial chemistry , organic chemistry , enzyme
A mild and efficient one‐pot method has been developed for the stereoselective synthesis of structurally diverse novel iminosugar C ‐alkynylglycosides. The generality of this methodology has been demonstrated with a wide variety of amines and copper acetylides. This one‐pot method has been exploited in the synthesis of new class of DNA cross‐linking agents, polyhydroxy 1‐vinyl‐tetrahydroindolizine derivatives.