A Palette of Fluorescent Thiophene‐Based Ligands for the Identification of Protein Aggregates | Zendy

Shirani Hamid | Zendy; Linares Mathieu | Zendy; Sigurdson Christina J. | Zendy; Lindgren Mikael | Zendy; Norman Patrick | Zendy; Nilsson K. Peter R. | Zendy

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A Palette of Fluorescent Thiophene‐Based Ligands for the Identification of Protein Aggregates

Author(s) -

Shirani Hamid,

Linares Mathieu,

Sigurdson Christina J.,

Lindgren Mikael,

Norman Patrick,

Nilsson K. Peter R.

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201502999

Subject(s) - thiophene , palette (painting) , fluorescence , chemistry , biophysics , photochemistry , organic chemistry , biology , computer science , physics , operating system , quantum mechanics

By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene‐based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease‐associated protein aggregates in tissue sections.

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