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A Palette of Fluorescent Thiophene‐Based Ligands for the Identification of Protein Aggregates
Author(s) -
Shirani Hamid,
Linares Mathieu,
Sigurdson Christina J.,
Lindgren Mikael,
Norman Patrick,
Nilsson K. Peter R.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502999
Subject(s) - thiophene , palette (painting) , fluorescence , chemistry , biophysics , photochemistry , organic chemistry , biology , physics , quantum mechanics , computer science , operating system
By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene‐based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease‐associated protein aggregates in tissue sections.