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Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ‐Fe 2 O 3 Phase
Author(s) -
Casterou Gérald,
Collière Vincent,
Lecante Pierre,
Coppel Yannick,
Eliat PierreAntoine,
Gauffre Fabienne,
Kahn Myrtil L.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502905
Subject(s) - materials science , transversal (combinatorics) , nanocrystal , phase (matter) , nanoparticle , hydrolysis , nuclear magnetic resonance , chemistry , nanotechnology , organic chemistry , mathematical analysis , physics , mathematics
Pure and highly crystalline γ‐Fe 2 O 3 nanocrystals (NCs) are obtained when hydrolysis and oxidation of a Fe II organometallic precursor are performed in successive steps. Their synthesis in pure alkylamine leads to NCs of about 6 nm. In aqueous solutions of poly(vinyl)pyrrolidone, such pristine NCs form aggregates of about 150 nm that exhibit a high transversal relaxivity ( r 2 =466 m M −1 s −1 ) about four times higher than that of a commercial Feridex magnetic resonance imaging (MRI) contrast agent. Consequently, they provide a significant decrease in the NMR signal at very short echo time (8 ms), which is of paramount importance in clinical practice because of the reduced duration of MRI measurements.