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A Mild and Regioselective Route to Functionalized Quinazolines
Author(s) -
Maiden Tracy M. M.,
Swanson Stephen,
Procopiou Panayiotis A.,
Harrity Joseph P. A.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502891
Subject(s) - regioselectivity , yield (engineering) , sequence (biology) , chemistry , combinatorial chemistry , catalysis , organic chemistry , stereochemistry , materials science , biochemistry , metallurgy
A Rh‐catalyzed ortho ‐amidation cyclocondensation sequence gave a range of 4‐aminoquinazolines in high yield. The method features a remarkably mild C(sp 2 )H activation step and can be exploited to rapidly access compounds with established biological activity.