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Catalytic Enantioselective Decarboxylative Allylations of a Mixture of Allyl Carbonates and Allyl Esters: Total Synthesis of (−)‐ and (+)‐Folicanthine
Author(s) -
Ghosh Santanu,
Chaudhuri Saikat,
Bisai Alakesh
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502878
Subject(s) - enantioselective synthesis , total synthesis , enol , chemistry , catalysis , organic chemistry
A highly enantioselective decarboxylative allylation of a mixture of enol carbonates and allyl esters has been achieved. The strategic viability of this methodology has been demonstrated through the total synthesis of cyclotryptamine alkaloids (−)‐ and (+)‐folicanthine ( 1 a ) and the formal total synthesis of (−)‐chimonanthine ( 1 b ), (+)‐calycanthine ( 1 c ), and (−)‐ditryptophenaline ( 1 d ).