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Hybrid Diphenylalkyne–Dipeptide Oligomers Induce Multistrand β‐Sheet Formation
Author(s) -
Ross Jonathan E.,
Knipe Peter C.,
Thompson Sam,
Hamilton Andrew D.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502690
Subject(s) - dipeptide , biophysics , mediation , materials science , nanotechnology , molecule , chemistry , biochemistry , peptide , biology , political science , law , organic chemistry
Functionalized diphenylalkynes provide a template for the presentation of protein‐like surfaces composed of multistrand β‐sheets. The conformational properties of three‐, four‐, and seven‐stranded systems have been investigated in the solid‐ and solution‐state. This class of molecule may be suitable for the mediation of therapeutically relevant protein–protein interactions.