Palladium‐Catalyzed Arylation of Unactivated γ‐Methylene C(sp 3 )H and δ‐CH Bonds with an Oxazoline‐Carboxylate Auxiliary | Zendy

Ling PengXiang | Zendy; Fang ShengLong | Zendy; Yin XueSong | Zendy; Chen Kai | Zendy; Sun BoZheng | Zendy; Shi BingFeng | Zendy

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Palladium‐Catalyzed Arylation of Unactivated γ‐Methylene C(sp 3 )H and δ‐CH Bonds with an Oxazoline‐Carboxylate Auxiliary

Author(s) -

Ling PengXiang,

Fang ShengLong,

Yin XueSong,

Chen Kai,

Sun BoZheng,

Shi BingFeng

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201502621

Subject(s) - oxazoline , palladium , chemistry , carboxylate , catalysis , substrate (aquarium) , methylene , medicinal chemistry , trifluoromethyl , ether , nitro , amine gas treating , organic chemistry , oceanography , alkyl , geology

A palladium‐catalyzed arylation of unactivated γ ‐ methylene C(sp 3 )H and remote δ‐CH bonds by using an oxazoline‐carboxylate directing group has been developed. Arylation occurs with a broad substrate scope and high tolerance of functional groups (i.e., halogen, nitro, cyano, ether, trifluoromethyl, amine, and ester). The oxazoline‐type auxiliary can be removed under acidic conditions.

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