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“Two‐Step” Raman Imaging Technique To Guide Chemo‐Photothermal Cancer Therapy
Author(s) -
Deng Lin,
Li Qiujin,
Yang Yang,
Omar Haneen,
Tang Naijun,
Zhang Jianfei,
Nie Zhihong,
Khashab Niveen M.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502522
Subject(s) - photothermal therapy , doxorubicin , nanotechnology , nanorod , materials science , drug delivery , in vivo , raman spectroscopy , photothermal effect , endocytic cycle , surface enhanced raman spectroscopy , biomedical engineering , chemotherapy , medicine , endocytosis , raman scattering , optics , biology , surgery , physics , microbiology and biotechnology , receptor
Graphene oxide‐wrapped gold nanorods (GO@AuNRs) offer efficient drug delivery as well as NIR laser photothermal therapy (PTT) in vitro and in vivo. However, no real‐time observation of drug release has been reported to better understand the synergy of chemotherapy and PTT. Herein, surface‐enhance Raman spectroscopy (SERS) is employed to guide chemo‐photothermal cancer therapy by a two‐step mechanism. In the presence of GO as an internal standard, SERS signals of DOX (doxorubicin) loaded onto GO@AuNRs are found to be pH‐responsive. Both DOX and GO show strong SERS signals before the DOX@GO@AuNRs are endocytic. However, when the DOX@GO@AuNRs enter acidic microenvironments such as endosomes and/or lysosomes, the DOX signals start decreasing while the GO signals remain the same. This plasmonic antenna could be used to identify the appropriate time to apply the PTT laser during chemo‐photothermal therapy.