Diastereo‐ and Enantioselective Iridium Catalyzed Carbonyl (α‐Cyclopropyl)allylation via Transfer Hydrogenation | Zendy

Tsutsumi Ryosuke | Zendy; Hong Suckchang | Zendy; Krische Michael J. | Zendy

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Diastereo‐ and Enantioselective Iridium Catalyzed Carbonyl (α‐Cyclopropyl)allylation via Transfer Hydrogenation

Author(s) -

Tsutsumi Ryosuke,

Hong Suckchang,

Krische Michael J.

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201502499

Subject(s) - iridium , enantioselective synthesis , transfer hydrogenation , aldehyde , cyclopropane , catalysis , chemistry , organic chemistry , alcohol , noyori asymmetric hydrogenation , ruthenium , ring (chemistry)

The first examples of diastereo‐ and enantioselective carbonyl α‐(cyclopropyl)allylation are reported. Under the conditions of iridium catalyzed transfer hydrogenation using the chiral precatalyst ( R )‐Ir‐ I modified by SEGPHOS, carbonyl α‐(cyclopropyl)allylation may be achieved with equal facility from alcohol or aldehyde oxidation levels. This methodology provides a conduit to hitherto inaccessible inaccessible enantiomerically enriched cyclopropane‐containing architectures.

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