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A Bioinspired Catalytic Aerobic Oxidative CH Functionalization of Primary Aliphatic Amines: Synthesis of 1,2‐Disubstituted Benzimidazoles
Author(s) -
Nguyen Khac Minh Huy,
Largeron Martine
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502487
Subject(s) - surface modification , catalysis , primary (astronomy) , chemistry , environmentally friendly , oxidative phosphorylation , combinatorial chemistry , oxidative coupling of methane , organic chemistry , biochemistry , physics , astronomy , ecology , biology
Aerobic oxidative CH functionalization of primary aliphatic amines has been accomplished with a biomimetic cooperative catalytic system to furnish 1,2‐disubstituted benzimidazoles that play an important role as drug discovery targets. This one‐pot atom‐economical multistep process, which proceeds under mild conditions, with ambient air and equimolar amounts of each coupling partner, constitutes a convenient environmentally friendly strategy to functionalize non‐activated aliphatic amines that remain challenging substrates for non‐enzymatic catalytic aerobic systems.