Premium
A Versatile Approach to CF 3 ‐Containing 2‐Pyrrolidones by Tandem Michael Addition–Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors
Author(s) -
Mateu Natalia,
Ciordia Myriam,
Delgado Oscar,
SánchezRoselló María,
Trabanco Andrés A.,
Van Gool Michiel,
Tresadern Gary,
PérezBenito Laura,
Fustero Santos
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502483
Subject(s) - exemplification , tandem , michael reaction , amidine , sketch , chemistry , computer science , combinatorial chemistry , stereochemistry , philosophy , biochemistry , engineering , algorithm , catalysis , linguistics , aerospace engineering
The groups of Santos Fustero at the University of Valencia (Spain) and Oscar Delgado at Janssen Research and Development (Spain) have been invited for the front cover of this issue. The image depicts the docking of one of the β‐secretase 1 (BACE1) inhibitors encapsulated in a sketch of the human brain. Read the full text of the article at 10.1002/chem.201501662 .