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Room‐Temperature Decarboxylative Couplings of α‐Oxocarboxylates with Aryl Halides by Merging Photoredox with Palladium Catalysis
Author(s) -
Cheng WanMin,
Shang Rui,
Yu HaiZhu,
Fu Yao
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502286
Subject(s) - palladium , iridium , halide , aryl , catalysis , chemistry , photoredox catalysis , catalytic cycle , photochemistry , photocatalysis , organic chemistry , alkyl
Enabled by merging iridium photoredox catalysis and palladium catalysis, α‐oxocarboxylate salts can be decarboxylatively coupled with aryl halides to generate aromatic ketones and amides at room temperature. DFT calculations suggest that this reaction proceeds through a Pd 0 –Pd II –Pd III pathway, in which the Pd III intermediate is responsible for reoxidizing Ir II to complete the Ir III –*Ir III –Ir II photoredox cycle.