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Drug Delivery Nanocarriers from a Fully Degradable PEG‐Conjugated Polyester with a Reduction‐Responsive Backbone
Author(s) -
Yameen Basit,
Vilos Cristian,
Choi Won Il,
Whyte Andrew,
Huang Jining,
Pollit Lori,
Farokhzad Omid C.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502233
Subject(s) - nanocarriers , polyester , peg ratio , drug delivery , conjugated system , intracellular , polyethylene glycol , nanoparticle , chemistry , combinatorial chemistry , materials science , polymer , biophysics , nanotechnology , organic chemistry , biochemistry , finance , economics , biology
The remarkably high intracellular concentration of reducing agents is an excellent endogenous stimulus for designing nanocarriers programmed for intracellular delivery of therapeutic agents. However, despite their excellent biodegradability profiles, aliphatic polyesters that are fully degradable in response to the intracellular reducing environment are rare. Herein, a reduction‐responsive drug delivery nanocarrier derived from a linear polyester bearing disulfide bonds is reported. The reduction‐responsive polyester is synthesized via a convenient polycondensation process. After conjugation of terminal carboxylic acid groups of polyester to polyethylene glycol (PEG), the resulting polymer self‐assembles into nanoparticles that are capable of encapsulating dye and anticancer drug molecules. The reduction‐responsive nanoparticles display a fast payload release rate in response to the intracellular reducing environment, which translates into superior anticancer activity towards PC‐3 cells.