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Construction of a Near‐Infrared Fluorescent Turn‐On Probe for Selenol and Its Bioimaging Application in Living Animals
Author(s) -
Chen Hua,
Dong Baoli,
Tang Yonghe,
Lin Weiying
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502226
Subject(s) - selenocysteine , fluorescence , biocompatibility , turn (biochemistry) , chemistry , in vivo , nanotechnology , combinatorial chemistry , biochemistry , materials science , organic chemistry , cysteine , biology , physics , microbiology and biotechnology , enzyme , quantum mechanics
As selenocysteine (Sec) carries out the majority of the functions of the various Se‐containing species in vivo, it is of high importance to develop reliable and rapid assays with biocompatibility to detect Sec. Herein, an NIR fluorescent turn‐on probe for highly selective detection of selenol was designed and synthesized. The probe exhibits large turn‐on signal upon treatment with selenocysteine (R‐SeH), and it was further demonstrated that the new NIR fluorescent probe can be employed to image selenol in living animals.