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Synthesis and Analysis of the Structure, Diffusion and Cytotoxicity of Heterocyclic Platinum(IV) Complexes
Author(s) -
Macias Freddy J.,
Deo Krishant M.,
Pages Benjamin J.,
Wormell Paul,
Clegg Jack K.,
Zhang Yingjie,
Li Feng,
Zheng Gang,
Sakoff Jennette,
Gilbert Jayne,
AldrichWright Janice R.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502159
Subject(s) - platinum , cytotoxicity , chemistry , diffusion , combinatorial chemistry , nuclear chemistry , organic chemistry , biochemistry , in vitro , catalysis , physics , thermodynamics
We have developed six dihydroxidoplatinum(IV) compounds with cytotoxic potential. Each derived from active platinum(II) species, these complexes consist of a heterocyclic ligand (H L ) and ancillary ligand (A L ) in the form [Pt(H L )(A L )(OH) 2 ] 2+ , where H L is a methyl‐functionalised variant of 1,10‐phenanthroline and A L is the S,S or R,R isomer of 1,2‐diaminocyclohexane. NMR characterisation and X‐ray diffraction studies clearly confirmed the coordination geometry of the octahedral platinum(IV) complexes. The self‐stacking of these complexes was determined using pulsed gradient stimulated echo nuclear magnetic resonance. The self‐association behaviour of square planar platinum(II) complexes is largely dependent on concentration, whereas platinum(IV) complexes do not aggregate under the same conditions, possibly due to the presence of axial ligands. The cytotoxicity of the most active complex, exhibited in several cell lines, has been retained in the platinum(IV) form.