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Catalytic Asymmetric Bromination of Unfunctionalized Olefins with H 2 O as a Nucleophile
Author(s) -
Zhang Xun,
Li Jing,
Tian Hua,
Shi Yian
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201502133
Subject(s) - nucleophile , halogenation , catalysis , chemistry , organic chemistry , medicinal chemistry , polymer chemistry
The dimeric cinchona alkaloid (DHQD) 2 PHAL is used to catalyze an effective asymmetric bromohydroxylation of unfunctionalized olefins with H 2 O as nucleophile an N ‐bromobenzamide as a bromine source. A variety of optically active bromohydrins are formed with up to 88 % ee .